Dependency of Calcium Alternans on Ryanodine Receptor Refractoriness
نویسندگان
چکیده
منابع مشابه
Dependency of Calcium Alternans on Ryanodine Receptor Refractoriness
BACKGROUND Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium released from the sarcoplasmic reticulum (SR). However, the relationship between calcium alternans and refractoriness of the SR calcium release channel (RyR2) remains elusive. METHODOLOGY/PRINCIPAL FINDINGS To investigate how ryanodine receptor (RyR2) refractoriness modul...
متن کاملMinimal model for calcium alternans due to SR release refractoriness.
In the heart, rapid pacing rates may induce alternations in the strength of cardiac contraction, termed pulsus alternans. Often, this is due to an instability in the dynamics of the intracellular calcium concentration, whose transients become larger and smaller at consecutive beats. This alternation has been linked experimentally and theoretically to two different mechanisms: an instability due...
متن کاملOptical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillation.
RATIONALE Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia. OBJECTIVE To measure intra-SR free [Ca(2+)] ([Ca(2+)]SR) changes in intact hearts during alternans and ventricular fibrillation (VF). METHODS AND RESULTS Simultaneous optical mapping of Vm (with RH237) and [Ca(2+)]SR ...
متن کاملAlternans goes subcellular: a "disease" of the ryanodine receptor?
In 1872 Traube 1 first described pulsus alternans, a regular beat-to-beat alternation of the strength of the heartbeat. Since then, cardiologists and physiologists have learned that cardiac alternans can come in many flavors: as mechanical, electrical, or [Ca ]i transient alternans (Ca alternans).2 They also had to realize that alternans is a life-threatening condition, less so because of impai...
متن کاملRyanodine receptor calcium release channels.
The ryanodine receptors (RyRs) are a family of Ca2+ release channels found on intracellular Ca2+ storage/release organelles. The RyR channels are ubiquitously expressed in many types of cells and participate in a variety of important Ca2+ signaling phenomena (neurotransmission, secretion, etc.). In striated muscle, the RyR channels represent the primary pathway for Ca2+ release during the excit...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0055042